Ion Channels & Transporters in Immunity

The Concepcion Lab at the University of Chicago investigates how ion channels  regulate immune cell signaling and function. We combine cross-disciplinary approaches to understand the complex molecular networks regulated by ion channels in immune cells. Our goal is to identify and characterize novel, specific and functional ion channels in immune cells to gain better understanding of how these proteins regulate the immune response and make fundamental and translational advances in immunotherapy.

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Cryo-EM structure of the human LRRC8A channel (source: RCSB PDB)
Mutations in LRRC8A have been linked with immunodeficiency disorder

To Discover

We use functional genomics and forward genetic screens to identify novel membrane proteins and ion channel regulators of immune cells.

To Understand

We employ biochemistry, structural biology, electrophysiology, and a wide range of molecular biology techniques to unveil the mechanisms underlying ion channel regulation of immune cell function.

To Heal

We assess ion channels and transporters as therapeutic targets in in vivo mouse models of infection, autoimmunity, and cancer. Our goal is to identify novel potential targets for immunotherapy.

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Publications

The role of ion channels in physiology

Ion channels are fascinating membrane proteins that have captivated the attention of scientists for decades. These remarkable proteins are responsible for the permeation of ions across cell membranes, allowing for the regulation of crucial physiological processes. They play a crucial role in maintaining the electrical excitability of neurons and muscle fibers, enabling the transmission of signals and the initiation of action potentials. In excitable cells, ion channels orchestrate the delicate balance of ions, such as potassium (K_⁺), sodium (Na_⁺), calcium (Ca_²⁺), and others, across the cell membranes. By precisely controlling the movement of these ions, ion channels contribute to the generation and propagation of electrical signals, ultimately governing neuronal communication and muscle contraction.

Why do we study ion channels in immune cells?

While the role of ion channels in excitable cells is well-established, their significance in non-excitable cells, such as immune cells, is still emerging. Recent studies have shed light on the critical involvement of ion channels in immune cell function and immune responses. Loss-of function and null mutations of specific ion channel genes in humans and mice have revealed their essential contributions to immune cell activity.

The mammalian genome encodes several hundred ion channels, each with its unique properties and functions. However, only a limited number of ion channels have been extensively characterized in immune cells thus far. This presents an exciting opportunity for research and exploration, as there is still much to learn about these enigmatic proteins in the context of immunology.

Our contribution to this emerging research field in immunology

To unlock the potential of ion channels in immunology, our dedicated team is actively engaged in a systematic effort to discover and characterize novel ion channels that regulate immune cell function. Through meticulous research and experimentation, we aim to unveil the mysteries surrounding these proteins and uncover their intricate roles in immune responses. We are optimistic that our endeavors will contribute to advancing our knowledge of immunology and pave the way for innovative therapeutic interventions.

Why is our research important?

The intricate world of ion channels offers a realm of possibilities in understanding the complexities of immune cell function and immune responses. Understanding the role of ion channels in immune cells could have significant implications for the development of novel therapeutic strategies. Targeting ion channels located on the surface of immune cells could provide new avenues for immunotherapy, as these proteins represent potential targets for modulating immune responses.