By Jemma Strauss & Anant B. Parekh. Cell Calcium, 2022.
New roles for the β1 subunit in regulating T cells. In excitable cells, β regulates trafficking and gating of voltage-operated Ca2+ channels (VOCCs). The new work by Feske, Prakriya et al. now unequivocally rule out functional VOCCs in murine and human T cells. The major route for Ca2+ entry is through Orai1, activated by the ER-resident STIM proteins. Roles for β subunit independent of VOCC regulation include control of other ion channels, as well as a host of intracellular mechanisms that might be connected.
https://www.sciencedirect.com/science/article/abs/pii/S0143416022001051?via%3Dihub
By Sonia Missiroli, Carlotta Giorgi & Paolo Pinton. Cell Calcium, 2022.
Up to now, no role has been associated with VRAC channels in T cells. In a recent paper published in Nature Immunology, LRRC8C has been described as an essential component of VRAC in T cells. These data raise the intriguing possibility that the LRRC8C-STING-p53 signaling axis may represent a new inhibitory pathway in T cells that controls their function and adaptive immunity.
https://www.sciencedirect.com/science/article/abs/pii/S0143416022000707
By Michael D. Cahalan. Science Signaling, 2022.
Calcium (Ca2+) signaling has long been known to be crucial for T cell activation. Erdogmus et al. tested the function of voltage-gated Ca2+ channel (CaV) proteins and discovered a nonchannel function mediated by an accessory subunit but found no evidence for CaV channel activity in T cells.
https://www.science.org/doi/10.1126/scisignal.abq5594
By John F. Foley. Science Signaling, 2022.
The cyclic dinucleotide cGAMP taken up through the anion channel component LRRC8C suppresses T cell function.
https://www.science.org/doi/10.1126/scisignal.abo4600
By Jiachen Chu & Zhaozhu Qiu. Nature Immunology, 2022.
LRRC8C is an essential component of volume-regulated anion channel (VRAC) in T cells. By mediating the transport of cGAMP, LRRC8C inhibits T cell function by activating STING and the tumor suppressor p53.
https://www.nature.com/articles/s41590-021-01118-6
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